3FunMap: Full-sib family functional mapping tools. (Version 1.0)
3FunMap is a Windows software that can be used to construct genetic linkage maps and perform functional QTL mapping
with molecular markers generated in a full-sib family. For linkage analysis, the software utilizes seven segregation
types of markers to estimate the recombination and simultaneously predict the linkage phase between any two markers.
It takes heuristic search method for ordering large number of markers of a linkage group by incorporating local ordering
methods. Multi-locus linkage phases for the optimal order of each linkage group are predicted based on three-point
For functional QTL mapping, the algorithm is based on interval mapping method, and the growth trajectory is described
by Legendre polynomial. The QTL segregation patterns are considered to be sorted into three types, full cross
(segregating 1:1:1:1), F2 cross (segregating 1:2:1), and test cross (segregating 1:1). The model selection criteria
of AIC and BIC are applied not only to determine the order of Legendre polynomial, but also to discriminate the QTL
segregation pattern. 3FunMap can plot the log-likelihood ratio (LR) profiles along the whole genome and the Legendre
polynomial curves for each QTL genotype. In practical QTL mapping, the threshold of LR for each QTL model can be
obtained through permutations.
For more details, please refer to the document.
The windows version and the document can be downloaded from the following link.
||Please click the graph to get the original one.
|Figure1: Linkage result|
|Figure2: LR profile|
|Figure3: Genotype curves|
03/03/2011: Version 1.0 is Released